Leah Pandiscia, PhD
July 28, 2017
Pathogenic Leptospirais the causative agent of leptospirosis, a wide disseminated disease of human and veterinary concern. The development ofvaccines that… Continue reading Immune response and protective profile elicited by a multi-epitope chimeric protein derived from Leptospira interrogans
Leah Pandiscia, PhD
July 28, 2017
Cell-penetrating peptides are short cationic peptides with inherent ability to cross the plasma membrane barrier as well as intracellularly deliver… Continue reading Cell-penetrating and cargo-delivery ability of a spider toxin-derived peptide in mammalian cells
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Eugenol has attracted considerable attention because of its potential for many pharmaceutical applications including anti-inflammatory, anti-tumorigenic and anti-oxidant properties. Here,… Continue reading Eugenol prevents amyloid formation of proteins and inhibits amyloid-induced hemolysis
Leah Pandiscia, PhD
July 28, 2017
Previously, our group isolated and evaluated anti-ricin single domain antibodies (sdAbs) derived from llamas, engineered them to further increase their… Continue reading Pairing Alpaca and Llama-Derived Single Domain Antibodies to Enhance Immunoassays for Ricin
Leah Pandiscia, PhD
July 28, 2017
The aggregation of amyloid-Aβ (Aβ) on lipid bilayers has been implicated as a mechanism by which Aβ exerts its toxicity… Continue reading Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β
Leah Pandiscia, PhD
July 28, 2017
Cell-penetrating peptides (CPP) have attracted many scientists’ attention as intracellular delivery tools due to their high cargo molecule transportation efficiency… Continue reading Development of helix-stabilized cell-penetrating peptides containing cationic α,α-disubstituted amino acids as helical promoters
Leah Pandiscia, PhD
July 28, 2017
Toll-like receptors (TLRs) mediate immune responses upon recognition of a variety of ligands. To further elucidate the function of TLRs,… Continue reading Preparation of the Extracellular Domain of Recombinant Human Toll-like Receptor 6
Leah Pandiscia, PhD
July 28, 2017
CVB3 is a common human pathogen to be highly lethal to newborns and causes viral myocarditis and pancreatitis in adults.… Continue reading Intein-mediated backbone cyclization of VP1 protein enhanced protection of CVB3-induced viral myocarditis
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Phafin2 is a phosphatidylinositol 3-phosphate (PtdIns(3)P) binding protein involved in the regulation of endosomal cargo trafficking and lysosomal induction of… Continue reading Structural, thermodynamic, and phosphatidylinositol 3-phosphate binding properties of Phafin2
Leah Pandiscia, PhD
July 28, 2017
Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new… Continue reading Aristolochic acid derivatives from the rhizome of Arisolochia championii
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Host defence peptides (HDPs) are short, cationic amphipathic peptides that play a key role in the response to infection and… Continue reading Novel human bioactive peptides identified in Apolipoprotein B: Evaluation of their therapeutic potential
Leah Pandiscia, PhD
July 28, 2017
Andraca droppings are the waste excreted by the tea biter, Andraca theae. Their chemical constituents and potential medical use, unlike those of… Continue reading Tea silkworm droppings as an enriched source of tea flavonoids
Leah Pandiscia, PhD
July 28, 2017
Two pairs of chiral Zn(II) complexes, Zn((−)-L1)Cl2 ((−)-1) and Zn((+)-L1)Cl2 ((+)-1), Zn((−)-L2)Cl2 ((−)-2) and Zn((+)-L2)Cl2 ((+)-2), [(−)-L1 = (−)-4,5-pinene bipyridine, (+)-L1= (+)-4,5-pinene bipyridine, (−)-L2 = (−)-‘dipineno’-[4,5:4″,5″]-fused… Continue reading Distinct optoelectronic properties of four-coordinate and five-coordinate Zn(II) complexes with chiral polypyridine ligands
Leah Pandiscia, PhD
July 28, 2017
The amido-Schiff base 1 (N1, N3-bis (2-nitrobenzylidene)benzene-1,3-dicabohydrazide) containing a single bondCONHsingle bond group and single bondCHdouble bond; length as m-dashNsingle bond linkage has been synthesized by… Continue reading A selective chemosensor for fluoride ion and its interaction with Calf Thymus DNA
Leah Pandiscia, PhD
July 28, 2017
Four new iridoids, 2’-O-trans-coumaroylshanzhiside (1), 6’-O-trans-coumaroyl- shanzhiside (2), 8α-butylgardenoside B (3), 6α-methoxygenipin (4), and one new phenylpropanoid glucoside, 4-methoxy-benzenepropanol-3-O-β-D-glucopyranoside (5),… Continue reading Chemical constituents from the flowers of wild Gardenia jasminoides Ellis
Leah Pandiscia, PhD
July 28, 2017