Recapitulation of the articular cartilage microenvironment for regenerative medicine applications faces significant challenges due to the complex and dynamic biochemical… Continue reading Enhanced Articular Cartilage by Human Mesenchymal Stem Cells in Enzymatically Mediated Transiently RGDS–Functionalized Collagen–Mimetic Hydrogels
Leah Pandiscia, PhD
July 28, 2017
Antimicrobial peptides (AMPs) occur widely in nature and have been studied for their therapeutic potential. AMPs are of interest due… Continue reading Hydrocarbon-stapled lipopeptides exhibit selective antimicrobial activity
Leah Pandiscia, PhD
July 28, 2017
Huntington’s disease is caused by a CAG trinucleotide expansion mutation in the Huntingtin gene that leads to an artificially long… Continue reading Conformational dynamics and self-association of intrinsically disordered Huntingtin exon 1 in cells
Leah Pandiscia, PhD
July 28, 2017
The self-assembly of proteins into fibrillar structures called amyloid fibrils underlies the onset and symptoms of neurodegenerative diseases, such as… Continue reading Two-Step Amyloid Aggregation: Sequential Lag Phase Intermediates
Leah Pandiscia, PhD
July 28, 2017
This study presents an adenosine (A)-based molecular beacon (MB) for selective detection of Naja atra cardiotoxin (CTX) that functions by utilizing the… Continue reading Detection of Naja atra Cardiotoxin Using Adenosine-Based Molecular Beacon
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Human islet amyloid polypeptide (hIAPP), also known as amylin, is a 37 residue peptide hormone that is stored and co-secreted… Continue reading Peptide Conjugates of Benzene Carboxylic Acids as Agonists and Antagonists of Amylin Aggregation
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
The structural and biophysical properties typically associated with G-quadruplex (G4) structures renders them a significant block for DNA replication, which… Continue reading Residues in the RecQ C-terminal Domain of the Human Werner Syndrome Helicase are Involved in Unwinding G-quadruplex DNA
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
A simple and efficient construction of a water-soluble glycoconjugate bearing a cyanostilbene with glucose pendant and its interaction with proteins… Continue reading Carbohydrate Tethered Cyanostilbene Fluorogen: Unique Emission and Preferential Protein Binding
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Chemotherapy resistant leukemic stem cells (LSCs) are being targeted as a modern therapeutic approach to prevent disease relapse. LSCs isolated… Continue reading CD25 targeted therapy of chemotherapy resistant leukemic stem cells using DR5 specific TRAIL peptide
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Helix A and -C of α-Lactalbumin, a loosely folded amphitropic protein, perturb lipid monolayers by the formation of amyloid pore-like… Continue reading Peptides derived from α-Lactalbumin membrane binding helices oligomerize in presence of lipids and disrupt bilayers
Leah Pandiscia, PhD
July 28, 2017
Negatively charged side chains are important for the function of particular ion channels and certain other membrane proteins. To investigate… Continue reading Influence of glutamic acid residues and pH on the properties of transmembrane helices
Leah Pandiscia, PhD
July 28, 2017
Mercury ion (Hg2+) pollution has deleterious effects on the environment and human health. Herein, through one-step biomimetic mineralization of metal… Continue reading Biomimetic Construction of Protein-Conjugated Gold Clusters for Detecting Hg2+
Leah Pandiscia, PhD
July 28, 2017