Supramolecular rearrangements are crucial in determining the response of stimuli sensitive soft matter systems such as those formed by mixtures… Continue reading Supramolecular assembly of thermoresponsive steroidal surfactant with oppositely charged thermoresponsive block copolymer
Leah Pandiscia, PhD
July 28, 2017
Synthetic (glyco-)peptides inspired by proteins able to self-assemble are appealing biomaterials in the field of tissue engineering and regenerative medicine.… Continue reading Photoinduced Thiol-ene chemistry applied to the synthesis of elastin-inspired self-assembling glycopeptides
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Non-viral vectors for gene therapy such as DNA-cationic probe complexes offer important bio-safety advantages over viral approaches, due to their… Continue reading Effective control of the intrinsic DNA morphology by photosensitive polyamines
Leah Pandiscia, PhD
July 28, 2017
The research on secondary metabolites of Aspergillus lentulus afforded eight unusual heterodimeric tetrahydroxanthone derivatives, lentulins A−H (2−9), along with the known compound… Continue reading Unusual dimeric tetrahydroxanthone derivatives from Aspergillus lentulus and the determination of their axial chiralities
Leah Pandiscia, PhD
July 28, 2017
It is important to identify hotspot residues that determine protein-protein interactions in interfaces of macromolecular complexes. We have applied a… Continue reading Combining ancestral sequence reconstruction with protein design to identify an interface hotspot in a key metabolic enzyme complex
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Among Enterobacteriaceae, CTX-M type extended spectrum beta lactamase confers potent hydrolytic activity against cephalosporin group of antibiotics. Strains producing CTX-M type beta… Continue reading Structural insight into mode of binding of Meropenem to CTX-M-15 type β-lactamase
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Parkinson’s disease (PD) presents with neuropathological inclusions called Lewy bodies, which are primarily composed of fibrillar α-synuclein. Recently, we characterized… Continue reading Analysis of sheep α-synuclein provides a molecular strategy for the reduction of fibrillation
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
One of the proposed mechanisms of homocysteine (Hcy) toxicity is the post-translational modification of proteins by its metabolite, homocysteine thiolactone… Continue reading Conformational status of cytochrome c upon N-homocysteinylation: Implications to cytochrome c release
Leah Pandiscia, PhD
July 28, 2017
We have used chemical synthesis, electron paramagnetic resonance (EPR), and circular dichroism to detect and analyze the structural dynamics of… Continue reading Calcium-Dependent Structural Dynamics of a Spin-Labeled RyR Peptide Bound to Calmodulin
Leah Pandiscia, PhD
July 28, 2017
Neuraminidase 1 (NEU1) is a lysosomal sialidase catalyzing the removal of terminal sialic acids from sialyloconjugates. A plasma membrane-bound NEU1… Continue reading New Insights into Molecular Organization of Human Neuraminidase-1: Transmembrane Topology and Dimerization Ability
Leah Pandiscia, PhD
July 28, 2017
Sequence comparisons showed that the sulfur oxygenase reductase (SOR) of the haloalkaliphilic bacterium Thioalkalivibrio paradoxus Arh 1 (TpSOR) is branching deeply within… Continue reading A Sulfur Oxygenase from the Haloalkaliphilic Bacterium Thioalkalivibrio paradoxus with atypically low Reductase Activity
Leah Pandiscia, PhD
July 28, 2017
The aggregation of membrane-bound α-synuclein (αS) into oligomers and/or amyloid fibrils has been suggested to cause membrane damage in in vitro model… Continue reading Membrane-Bound Alpha Synuclein Clusters Induce Impaired Lipid Diffusion and Increased Lipid Packing
Leah Pandiscia, PhD
July 28, 2017
The construction of DNA-carbon dot (CD) hybrid hydrogel for targeted and sustained release of drug molecules is reported here. Amine… Continue reading Carbon dots assisted formation of DNA hydrogel for sustained release of drug
Leah Pandiscia, PhD
July 28, 2017
A dual functional AIE active amphiphilic molecule, sodium N,N’-bis[4-(3-sulfonatopropoxyl)] salicylidene (BSPS), was designed and synthesized. Due to its amphiphilic nature, BSPS could spontaneously… Continue reading A Dual Functional Fluorescent Sensor for Human Serum Albumin and Chitosan
Leah Pandiscia, PhD
July 28, 2017
Amyloid β-peptide (Aβ) is now considered as a key predictor for preclinical diagnosis of Alzheimer’s disease (AD), whose diagnosis is… Continue reading Colorimetric sandwich immunosensor for Aβ(1-42) based on dual antibody-modified gold nanoparticles
Leah Pandiscia, PhD
July 28, 2017
Protease inhibitors are essential bio-molecules that serve as a model system for the study of protein structure and protease-protease inhibitor… Continue reading Structure-function relationship of a bio-pesticidal trypsin/chymotrypsin inhibitor from winged bean
Leah Pandiscia, PhD
July 28, 2017