Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Mnemiopsin, an EF-hand Ca2+ binding photoprotein isolated from luminous ctenophoreMnemiopsis leidyi, emits blue light from its chromophore, coelenterazine, which is non-covalently… Continue reading Light induced structural changes of the photoprotein mnemiopsin: Characterization and contribution in photoinactivation
Leah Pandiscia, PhD
July 28, 2017
Four new azaphilones, peniazaphilones A–D (1–4), together with four analogues (5–8), were isolated from the alga-derived fungus Penicillium sp. ZJ-27. The structures… Continue reading Azaphilones isolated from an alga-derived fungus Penicillium sp. ZJ-27
Leah Pandiscia, PhD
July 28, 2017
One new bourbonane-type (1) and one new cadinane-type (2) sesquiterpenoids, along with one known aromodendrane-type (3) and five known megastigmane-type… Continue reading Sesquiterpenoids from the Chinese endangered plant Manglietia aromatica
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Relocation of a bioactive photosensitizer, namely phenosafranin (PSF), from the phenazinium family, has been demonstrated from non-ionic micellar carrier to… Continue reading Relocation of a biological photosensitizer from non-ionic micellar carrier to DNA: A multispectroscopic investigation
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Neo-tanshinlactone (NTL) a natural product is known for its specificity and selectivity towards the breast cancer cells. By NTL D-ring… Continue reading Neo-tanshinlactone D-Ring Modified Novel analogues Induce Apoptosis in Human Breast Cancer Cell via DNA Damage
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Knowledge of folding/unfolding pathway is fundamental basis to study protein structure and stability. Human carbonic anhydrase II (HCAII) is a… Continue reading Characterization of folding intermediates during urea-induced denaturation of human carbonic anhydrase II
Leah Pandiscia, PhD
July 28, 2017
Structure-specific ligands are convenient tools for the recognition, targeting or probing of noncanonical DNA structures. Porphyrin derivatives exhibit a preference… Continue reading Light-induced oxidation of the telomeric G4 DNA in complex with Zn(II) tetracarboxymethyl porphyrin
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
Leah Pandiscia, PhD
July 28, 2017
We have characterized two immunogenic proteins, Rv1197 and Rv1198, of the Esx-5 system of the ESAT-6 family of Mycobacterium tuberculosis… Continue reading Characterization of culture filtrate proteins Rv1197 and Rv1198 of ESAT-6 family from Mycobacterium tuberculosis H37Rv
Leah Pandiscia, PhD
July 28, 2017
Mycobacterium tuberculosis (M. tuberculosis) is the intracellular bacterium responsible for tuberculosis disease (TD). Inside the phagosomes of activated macrophages, M. tuberculosis is exposed… Continue reading PrxQ B from Mycobacterium tuberculosis is a monomeric, thioredoxin-dependent and highly efficient fatty acid hydroperoxide reductase
Leah Pandiscia, PhD
July 28, 2017
The interaction of minocyeline (MNC) with extracelluar protein (lysozyme, LYSO) or intracellular protein (bovine hemoglobin, BHb) was investigated using multi-spectral… Continue reading Interaction of the minocycline with extracelluar protein and intracellular protein by multi-spectral techniques and molecular docking
Leah Pandiscia, PhD
July 28, 2017
Quorum sensing systems are essential for bacterial communication. We report here the purification and characterization of the Pseudomonas aeruginosa LasR quorum sensing… Continue reading Purification and characterization of Pseudomonas aeruginosa LasR expressed in acyl-homoserine lactone free Escherichia coli cultures
Leah Pandiscia, PhD
July 28, 2017
Four new polyisoprenylated benzoylphloroglucinol derivatives, hyperscabrones J-M (1–4), were isolated from the air-dried aerial parts of Hypericum scabrum. Their structures were elucidated… Continue reading Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum
Leah Pandiscia, PhD
July 28, 2017