Found 9617 Results / Page 479 of 481
2016 / Genome Research
The CRISPR/Cas technology enables targeted genome editing and the rapid generation of transgenic animal models for the study of human… Continue reading Exome sequencing and CRISPR/Cas genome editing identify mutations of ZAK as a cause of limb defects in humans and mice
2016 / Helvetica Chimica Acta
Nineteen compounds mainly including pyrrole-containing alkaloids and phytosterols were isolated from the EtOH extract of the fermented mycelia of Xylaria nigripes,… Continue reading Chemical Constituents from the Fermented Mycelia of the Medicinal Fungus Xylaria nigripes
2016 / Journal of Chromatography A
Single step elution of a protein A column with 100 mM acetate pH 3.5 produced a curvilinear gradient with pH dropping… Continue reading Conformational plasticity of IgG during protein A affinity chromatography
2016 / Applied Microbiology and Biotechnology
Influence of surface charge, binding site residues and glycosylation on Thielavia terrestris cutinase biochemical characteristics
2016 / Tetrahedron
The topological study of novel quadruplex-forming DNA sequences found in immunoglobulin switch regions Sμ and Sγ3 is described along with… Continue reading Stabilization of novel immunoglobulin switch regions G-quadruplexes by naphthalene and quinoline-based ligands
2016 / Traffic
The adaptor protein 4 (AP4) complex (ϵ/β4/μ4/σ4 subunits) forms a non-clathrin coat on vesicles departing the trans-Golgi network. AP4 biology remains… Continue reading Molecular basis for the interaction between Adaptor Protein Complex 4 (AP4) β4 and its accessory protein, tepsin
2016 / Polymer
We report the preparation of biocompatible, dual stimuli-sensitive lipoic acid-modified poly(l-lysine) (PLL-g-Lipo) hydrogels/nanogels by chemical cross-link and polypeptide/silica hybrid hydrogels/nanogels… Continue reading Redox- and pH-Sensitive Lipoic Acid-Modified Poly(L-lysine) and Polypeptide/Silica Hybrid Hydrogels/Nanogels
2016 / The Journal of Antibiotics
A new natural product, designated iminimycin A, was isolated from the cultured broth of a streptomycin-producing microbial strain, Streptomyces griseus… Continue reading Iminimycin A, the new iminium metabolite produced by Streptomyces griseus OS-3601
2016 / Journal of Immunology
MHC class I (MHC I)–restricted virus-specific CTLs are implicated as critical components in the control of this naturally occurring lentivirus… Continue reading Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
2016 / Environmental Microbiology
TRAM domain proteins present in Archaea and Bacteria have a β-barrel shape with anti-parallel β-sheets that form a nucleic acid binding surface; a structure… Continue reading Single TRAM domain RNA-binding proteins in Archaea: functional insight from Ctr3 from the Antarctic methanogen Methanococcoides burtonii 1
2016 / Scientific Reports
A chiral tetraphenylethene derivative with two valine-containing attachments (TPE-DVAL), was synthesized by Cu(I)-catalyzed azide-alkyne “click” reaction. The optical properties and… Continue reading Synthesis, optical properties, and helical self-assembly of a bivalinecontaining tetraphenylethene
2016 / Phytochemistry
Anti-inflammatory coumarins with short- and long-chain hydrophobic groups from roots of Angelica dahurica cv. Hangbaizhi
2016 / Journal of Pharmaceutical Sciences
This study addressed the effect of contact sliding during stirring of a monoclonal antibody solution on protein aggregation, in particular,… Continue reading No Touching! Abrasion of Adsorbed Protein Is the Root Cause of Subvisible Particle Formation During Stirring
2016 / Biochemistry
The SET protein is a promising drug target in cancer therapy, because of its ability to inhibit the function of… Continue reading Using the MCoTI-II Cyclotide Scaffold To Design a Stable Cyclic Peptide Antagonist of SET, a Protein Overexpressed in Human Cancer
2016 / ACS Applied Materials and Interfaces
This study reports a method for the facile and high-yield exfoliation of WX2 (X = S, Se) by sonication under aqueous… Continue reading DNA-Assisted Exfoliation of Tungsten Dichalcogenides and Their Antibacterial Effect
2016 / Nano Letters
Chirality is a highly important topic in modern chemistry, given the dramatically different pharmacological effects that enantiomers can have on… Continue reading Hydrogen-Regulated Chiral Nanoplasmonics
2016 / Langmuir
Biocompatible liposomes were used for the first time to study the deintercalation process of a prominent anticancer drug, doxorubicin (DOX),… Continue reading First Evidence of the Liposome-Mediated Deintercalation of Anticancer Drug Doxorubicin from the Drug−DNA Complex: A Spectroscopic Approach
2016 / Langmuir
We discovered the unique cell adhesive properties of ultraviolet (UV)-irradiated albumin films. Albumin films prepared using a cross-linking reagent with… Continue reading Changes in Cell Adhesiveness and Physicochemical Properties of Cross-Linked Albumin Films after Ultraviolet Irradiation
2016 / Langmuir
Understanding complex chemical changes that take place at nano–bio interfaces is of great concern for being able to sustainably implement… Continue reading Nano−Bio Interactions of Porous and Nonporous Silica Nanoparticles of Varied Surface Chemistry: A Structural, Kinetic, and Thermodynamic Study of Protein Adsorption from RPMI Culture Medium
2016 / Macromolecules
The synthesis of multicomponent superhelices with determined chirality has been realized. By adding water to polymer solution in organic solvents… Continue reading Superhelices with Designed Helical Structures and Temperature-Stimulated Chirality Transitions
