A vibrational circular dichroism (VCD) system capable of microscopic scanning was developed. An intense infrared light from a quantum cascade… Continue reading Vibrational Circular Dichroism System Equipped with Quantum Cascade Laser for Microscopic Scanning
Satoko Suzuki
August 18, 2021
Self-assembling peptides have shown tremendous potential in the fields of material sciences, nanoscience, and medicine. Because of the vast combinatorial… Continue reading Rapid discovery of self-assembling peptides with one-bead one-compound peptide library
Carlos Morillo
August 2, 2021
Most biological and synthetic receptors for small organic molecules employ a combination of relatively weak intermolecular interactions such as hydrogen… Continue reading Molecular recognition by multiple metal coordination inside wavy-stacked macrocycles
Carlos Morillo
August 2, 2021
Herpes simplex virus is among the most prevalent sexually transmitted infections. Acyclovir is a potent, selective inhibitor of herpes viruses… Continue reading Pseudoboehmite as a drug delivery system for acyclovir
Carlos Morillo
August 2, 2021
Flotillins are the major structural proteins in erythroid raft domains. We have shown previously that the dynamic nanoscale organization of… Continue reading Molecular characterization of direct interactions between MPP1 and flotillins
Carlos Morillo
August 2, 2021
Human mitochondrial chaperonin mHsp60 is essential for mitochondrial function by assisting folding of mitochondrial proteins. Unlike the double-ring bacterial GroEL,… Continue reading Structural basis for the structural dynamics of human mitochondrial chaperonin mHsp60
Carlos Morillo
August 2, 2021
Two novel monoterpenoid indole alkaloids (MIAs), gelsechizines A-B (1–2), along with four known ones (3–6) were isolated from the fruits… Continue reading Monoterpenoid indole alkaloids from the fruits of Gelsemium elegans and their anti-inflammatory activities
Carlos Morillo
September 27, 2021
Carlos Morillo
August 2, 2021
Four previously unreported sesquiterpenoid diasteromers, arteannoides U–X (1–4), together with one new norsesquiterpenoid 5 (arteannoide Y) and one undescribed rearranged… Continue reading Arteannoides U–Z: Six undescribed sesquiterpenoids with anti-inflammatory activities from the aerial parts of Artemisia annua (Qinghao)
Carlos Morillo
August 2, 2021
Three new flavonoids, including a new prenylated aurone, 7,2′,5′-trihydroxy-8-prenylaurone (1), and two new flavanones, 2(S)-4′-hydroxy-6-methoxy-7-(2”-hydroxy-3”-methybult-3”-enyl)flavanone (2) and 2(S)-4′-hydroxy-7-methoxy-6-(1”,2”-epoxy-3”-hydroxy-dimethyl)flavanone (3), together… Continue reading Flavonoids from the seeds of Psoralea corylifolia inhibit diacylglycerol acyltransferase
Carlos Morillo
September 27, 2021
Two new tetrahydrobenzannulated 5,5-spiroketal sesquiterpenes (1 and 2) and three novel benzannulated 5,5-spiroketal sesquiterpenes (3–5) namely angepubesins A-E, together with… Continue reading Benzannulated 5,5-spiroketal sesquiterpenes from the roots of Angelica Pubescens
Carlos Morillo
September 27, 2021
Two new daphnane-type diterpenoids fischerianin A (1) and fischerianin B (2), as well as two known ones langduin A (3)… Continue reading Daphnane-type diterpenoids from Euphorbia fischeriana Steud and their cytotoxic activities
Carlos Morillo
September 27, 2021
The first phytochemical investigation from the stems of Croton krabas resulted in the isolation of three new ent-clerodane diterpenoids, crotonkrabases… Continue reading ent-Clerodane diterpenoids from the stems of Croton krabas
Carlos Morillo
September 27, 2021
Because of their stable orientations and their minimal interference with native DNA interactions and folding, emissive isomorphic nucleoside analogues are… Continue reading Synthesis and application of a 19F-labeled fluorescent nucleoside as a dual-mode probe for i-motif DNAs†
Carlos Morillo
August 2, 2021
Sorghum (Kaoliang) grain is an important crop with high economic value and several applications. In Taiwan, sorghum has been used… Continue reading Bioactive polyketides from the pathogenic fungus of Epicoccum sorghinum
Carlos Morillo
September 27, 2021
Selective solar absorbers (SSAs) with high performance are the key to concentrated solar power systems.Optical metamaterials are emerging as a… Continue reading High-temperature and abrasion-resistant metal-insulator-metalmetamaterials
Carlos Morillo
August 2, 2021
A wide variety of synthetic molecular machines has been designed and synthesized to construct nanometer-scale assemblies whose molecular motions can… Continue reading Stimuli-responsive Molecular Springs Based on Single- and Multi-stranded Helical Structures
Satoko Suzuki
July 28, 2021
Rational design of aptamers to incorporate unnatural nucleotides and special chemical moieties can expand their functional complexity and diversity. Spiegelmer… Continue reading Circular L-RNA aptamer promotes target recognition and controls gene activity
Satoko Suzuki
July 9, 2021
The critical dimension of semiconductor devices is approaching the single-nm regime, and a variety of practical devices of this scale… Continue reading Ubiquitous organic molecule-based free-standing nanowires with ultra-high aspect ratios
Carlos Morillo
July 6, 2021
We previously elucidated principles for designing ideal proteins with completely consistent local and non-local interactions which have enabled the design… Continue reading Role of backbone strain in de novo design of complex α/β protein structures
Carlos Morillo
July 6, 2021