The absolute configuration and corrected NMR assignment of 17-hydroxycyclooctatin isolated from Streptomyces sp. M56 recovered from a nest of South African Macrotermes natalensis termites… Continue reading Absolute Configuration and Corrected NMR Assignment of 17-Hydroxycyclooctatin, a Fused 5–8–5 Tricyclic Diterpene
Leah Pandiscia, PhD
June 29, 2020
Phytochemical investigation into the calyx of Physalis alkekengi L. var franchetii (Mast) Makino resulted in the isolation of ten cytotoxic withanolides, including five new… Continue reading Isolation and characterization of cytotoxic withanolides from the calyx of Physalis alkekengi L. var franchetii
Leah Pandiscia, PhD
June 29, 2020
Leah Pandiscia, PhD
June 29, 2020
Eight different culture media were used to culture shellfish Panopea abbreviate associated fungus Aspergillus sp. XBB-4. In a glucose-peptone-yeast (GPY) culture medium supplied with… Continue reading Cytotoxic alkaloids from the marine shellfish-associated fungus Aspergillus sp. XBB-4 induced by an amino acid-directed strategy
Leah Pandiscia, PhD
June 29, 2020
Leah Pandiscia, PhD
June 29, 2020
IAVPTGVA (Soy1) and LPYP are two soybean peptides, which display a multifunctional behavior, showing in vitro hypocholesterolemic and hypoglycemic activities.… Continue reading “Bottom-Up” Strategy for the Identification of Novel Soybean Peptides with Angiotensin-Converting Enzyme Inhibitory Activity
Leah Pandiscia, PhD
June 29, 2020
αO-conotoxin GeXIVA from Conus generalis is a potent antagonist of the α9α10 nAChR and analgesic in animal models of pain. This peptide… Continue reading Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA
Leah Pandiscia, PhD
June 29, 2020
N6-methyladenine (m6dA) has been recently discovered in eukaryotic genomic DNA. However, there have been few reports on its biological roles.… Continue reading Destabilisation of the c-kit1 G-quadruplex structure by N6-methyladenosine modification
Leah Pandiscia, PhD
June 29, 2020
Silkworm silk protein fibroin is widely exploited to develop novel silk-based biomaterials due to its stable β-sheet structure, providing high… Continue reading Glyoxal modification mediates conformational alterations in silk fibroin: Induction of fibrillation with amyloidal features
Leah Pandiscia, PhD
June 29, 2020
Leah Pandiscia, PhD
June 29, 2020
Chaperones are a diverse class of molecules known for increasing thermo-stability of proteins, preventing protein aggregation, favoring disaggregation, increasing solubility… Continue reading Application of a protein domain as chaperone for enhancing biological activity and stability of other proteins
Leah Pandiscia, PhD
June 29, 2020
Cytosolic protein delivery is important for the development of protein therapeutics towards intracellular targets. Guanidyl polymers exhibit high binding affinity… Continue reading Tailoring guanidyl-rich polymers for efficient cytosolic protein delivery
Leah Pandiscia, PhD
June 29, 2020
Investigations of the root extract of Dracaena usambarensis Engl. for anticancer principles led to the characterization of one new homoisoflavonoid, (3S)-3,4ʹ,5,6-tetrahydroxy-7-methoxyhomoisoflavanone (1)… Continue reading Two new flavonoids from Dracaena usambarensis Engl.
Leah Pandiscia, PhD
June 29, 2020
In this study, we report a diblock copolymer based on a polyphosphate backbone and pendant phenylboronic acid with glucose sensitivity.… Continue reading Glucose-Sensitive Polyphosphoester Diblock Copolymer for an Insulin Delivery System
Leah Pandiscia, PhD
June 29, 2020
Leah Pandiscia, PhD
June 29, 2020
Novel antimicrobial agents with a low propensity to develop resistance by microorganisms have contemporary relevance. In this perspective, the present… Continue reading Synthesis and characterization of cecropin peptide-based silver nanocomposites: Its antibacterial activity and mode of action
Leah Pandiscia, PhD
June 29, 2020
Chiral oligopeptide-naphthalene/Eu(III) hybridized luminophores emit strong circularly polarised solution-state luminescence (CPL) from Eu(III) at 592 and 614 nm (|gCPL| ≤… Continue reading Circularly polarised luminescence (CPL) control of oligopeptide–Eu(iii) hybridized luminophores by interaction with peptide side chains
Leah Pandiscia, PhD
June 29, 2020
Leah Pandiscia, PhD
June 29, 2020
Solvent chirality transfer using enantiomeric pairs of limonene and α-pinene allowed for the successful production of optically active poly(9,9-di-n-decylfluorene) (PF10) aggregates with circular dichroism (CD)… Continue reading Ambidextrous circular dichroism and circularly polarised luminescence from poly(9,9-di-n-decylfluorene) by terpene chirality transfer
Leah Pandiscia, PhD
June 29, 2020
An enantiopair of rigid rod-like helical polysilanes (PSi-S and PSi-R) as a photoscissible scaffold enabled the production of circularly polarised luminescence (CPL)-… Continue reading Aggregation-induced scaffolding: photoscissable helical polysilane generates circularly polarized luminescent polyfluorene
Leah Pandiscia, PhD
June 29, 2020