Title
A new nanosensor for the chiral recognition of cysteine enantiomers based on gold nanorods
Author
Ruijun Li, Chang-Long Zhu, Wang Li, Xintong Zhang, Yibing Ji
Year
2018
Journal
New Journal of Chemistry
Abstract
An easy-operation, celerity and high selectivity method, which applied unmodified Gold nanorods (GNRs) as a chiral nanosensor for the chiral recognition of cysteine (Cys) enantiomers, has been developed in this work. Under the optimized conditions, L-Cys caused the GNRs aggregation, and the absorbance decrease of GNRs at the wavelength of 650 nm was 0.601. However, the GNRs were almost monodispersion and the absorbance decrease was only 0.289 for D-Cys. Combined assay process with the optical rotation of GNRs, the chiral recognition phenomenon could be assigned that L-Cys induced the end-to-end assembly of GNRs through crosslinking agent Cu 2+ ions. The detection limit of this method for L-Cys was 0.325 μM. The relative standard deviation (RSD) was 1.5% for trace L-Cys, which indicated that the method presented good precision for the analysis of trace L-Cys in solution samples. Futhermore, we demonstrated that the nanosensor possessed a high selectivity for the chiral recognition of Cys enantiomers. The response of GNRs (△ALD) to Cys enantiomers was 7.8 times to Tryptophan (Try) enantiomers, and 9.2 times to Phenylalanine (Phe) enantiomers. In our perception, the assay showed new opportunities for efficient enantiosensing strategies.
Instrument
J-810
Keywords
Circular dichroism, Sensors, Nanostructures, Materials