A new polyketide synthase−nonribosomal peptide synthetase hybrid metabolite from plant endophytic fungus Periconia sp.
De-Wu Zhang, Xiao-Yu Tao, Ji-Mei Liu, Ri-Dao Chen, Min Zhang, Xiao-Mei Fang, Li-Yan Yu, Jun-Gui Dai
Chinese Chemical Letters
A new polyketide synthase–nonribosomal peptide synthetase (PKS–NRPS) hybrid metabolite, named pericoannosin B (1), was isolated from endophytic fungus Periconiasp. F-31 of the medicinal plant Annona muricata. The structure and absolute configuration were elucidated by means of extensive spectroscopic analyses (HRMS, NMR, IR, and CD).
Circular dichroism, Absolute configuration, Medicinal