Title
A novel adduct of ECG fused to piceid and four new dimeric stilbene glycosides from Polygonum cuspidatum
Author
Ya-nan Yang, Fu-shuang Li, Fu Liu, Zi-ming Feng, Jian-shuang Jiang, Pei-cheng Zhang
Year
2016
Journal
RSC Advances
Abstract
Polyflavanostilbene B (1), an unusual adduct of epicatechin-3-O-gallate fused to piceid through a carbon–carbon bond, four new dimeric stilbene glycosides (2–5), three new stilbene glucosides (6–8), one new flavan glucoside (9), and six known compounds were isolated from the rhizome ofPolygonum cuspidatum. The structures of these compounds were elucidated using spectroscopic data, including electronic circular dichroism (ECD) and Rh2(OCOCF3)4-induced CD spectra. All of the compounds were screened for their inhibitory activity against α-glucosidase using acarbose as a positive control (IC50 = 385 μM), and strong inhibitory activity against α-glucosidase was observed for compound 8 (IC50 = 3.04 μM).
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Medicinal