A novel C22 terpenoid from the cultured Perovskia atriplicifolia
Zhi-Yong Jiang, Le-Yu Zhu, Jun Zhou, Qiu-Fen Hu, Guang-Yu Yang, Xiang-Zhong Huang, Wen-Xing Liu, Lu Gao, Gan-Peng Li, Fu-Ting Xia
Helvetica Chimica Acta
A novel terpenoid, named perovskiaol (1), was isolated from the cultured Perovskia atriplicifolia. Its structure was elucidated by comprehensive spectroscopic analysis as well as by quantum chemical computation of electronic circular dichroism spectra. Perovskiaol (1) was a novel C22 terpenoid containing a unique D-ring simultaneously fused with rings A, B, and C, and encountered in nature for the first time. Cytotoxic bioassay suggested perovskiaol (1) possessed significant cytotoxic activity inhibiting NB4, A549, and HepG 2 cell lines with IC50 values of 2.35, 1.47, and 0.81 μm, respectively.
Circular dichroism, Absolute configuration, Medicinal