Title
Absolute configurations of phytotoxic inuloxins B and C based on experimental and computational analysis of chiroptical properties
Author
Marco Evidente, Ernesto Santoro, Ana G. Petrovic, Alessio Cimmino, Jun Koshoubu, Antonio Evidente, Nina Berova, Stefano Superchi
Year
2016
Journal
Phytochemistry
Abstract
The absolute configuration of phytotoxins inuloxins B and C, produced by Inula viscosa, and with potential herbicidal activity for the management of parasitic plants, has been determined by Time-dependent density functional theory computational prediction of electronic circular dichroism and optical rotatory dispersion spectra. The inuloxin B has been converted to its 5-O-acetyl derivative, which due to its more constrained conformational features facilitated the computational analysis of its chiroptical properties. The analysis based on experimental and computed data led to assignment of absolute configuration to naturally occurring (+)-inuloxin B and (−)-inuloxin C as (7R,8R,10S,11S) and (5S,7S,8S,10S), respectively.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal