Analysis of Cannabidiol in CBD products by SFC-CD-MS

November 9, 2021


Analysis of Cannabidiol in CBD products by SFC-CD-MS


DJ Tognarelli




Chromatography Today


Cannabinoid is a generic term for the chemical substances contained in cannabis plants. Tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD) are major components. THC is highly psychoactive and since 1970 has been classified as a schedule 1 drug in the US. Currently marijuana has been legalised for medicinal and recreational use in various countries around the world [1].

CBD has shown possible treatment effects for various disease states such as Alzheimer’s [2], Parkinson’s [3], psychosis and depression [4], as well as an effective remedy for pain due to its anti-inflammatory properties [5]. This compound doesn’t cause any psychological effects and therefore is not subject to abuse or physical/psychological dependence. CBD is not regulated by international regulations and products have already been approved as effective medicines for refractory epilepsy in the United States. In the Cannabis Control Law of Japan, the use of leaves, flowers, and roots from cannabis plants is banned as those parts contain a significant amount of THC. Seeds and stems are not regulated so development of CBD products extracted from these parts are legal.


SFC-4000, J-1500, LC-4000-MS


SFC, THC, cannabinoid