Title
Anti-Lymphangiogenesis Components from Zoanthid Palythoa tuberculosa
Author
Shu-Rong Chen, Shih-Wei Wang, Chien-Jung Su, Hao-Chun Hu, Yu-Liang Yan, Chi-Ting Hsieh, Chia-Chi Peng, Fang-Rong Chang, Yuan-Bin Cheng
Year
2018
Journal
Marine Drugs
Abstract
Three new compounds, tuberazines A–C (1–3), and eleven known compounds (4–14) were obtained from the ethanolic extract of Taiwanese zoanthid Palythoa tuberculosa. Compounds 1–4 are rare marine natural products with a pyrazine moiety, and compound 5 is a tricyclic tryptamine derivative isolated from nature for the first time. The structures of all isolated metabolites were determined by analyzing their IR, Mass, NMR, and UV spectrometric data. The absolute configuration of 1 was confirmed by comparing the trend of experimental electronic circular dichroism (ECD) with calculated ECD spectra. The anti-lymphangiogenic activities of new compounds were evaluated in human lymphatic endothelial cells (LECs). Of these, new compound 3 displayed the most potent anti-lymphangiogenesis property by suppressing cell growth and tube formation of LECs.
Full Article
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical, Medicinal