Title
Anti-neuroinflammatory constituents from the fungus Penicillium purpurogenum MHZ 111
Author
Jing Sun, Zhi-Xiang Zhu, Yue-Lin Song, Yi Ren, Dan Dong, Jiao Zheng, Ting Liu, Yun-Fang Zhao, Peng-Fei Tu, Jun Li
Year
2016
Journal
Natural Product Research
Abstract
A new dihydroisocoumarin (1) and a new coumarin (2), along with eight known metabolites (3–10), were isolated from the solid substrate fermentation cultures of the fungus Penicillium purpurogenum MHZ 111. Their structures were elucidated by extensive spectroscopic analysis and comparison of their spectroscopic and physicochemical data with the literature values. Compounds 2 and 8 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC50 values of 26.5 and 52.7 μM, respectively.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Medicinal