Asymmetric Synthesis and Stereochemical Assignment of 12C/13C Isotopomers

By Tomoya Miura, Takayuki Nakamuro, Yuuya Nagata, Daisuke Moriyama, Scott G. Stewart, and Masahiro Murakami

September 11, 2019

  • Year

  • Technique

  • Industry

Title

Asymmetric Synthesis and Stereochemical Assignment of 12C/13C Isotopomers

Author

Tomoya Miura, Takayuki Nakamuro, Yuuya Nagata, Daisuke Moriyama, Scott G. Stewart, and Masahiro Murakami

Year

2019

Journal

Journal of the American Chemical Society

Abstract

A synthesis of chiral hydrocarbons having C1 axis and C3 symmetry, which owe their chirality due to asymmetrical distribution of 12C/13C isotopes, is reported. Their absolute configurations assigned using the vibrational circular dichroism technique conform with those deduced from the absolute configurations of the parent α-formyl cyclopropanes.

Full Article

https://pubs.acs.org/action/showCitFormats?doi=10.1021%2Fjacs.9b07181

Instrument

VCD, FVS-6000

Keywords

FVS-6000, chiral, vibrational circular dichroism, isotopomers, α-formyl cyclopropanes