Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107

By Jixing Peng, Xiaomin Zhang, Wei Wang, Tianjiao Zhu, Qianqun Gu, Dehai Li

July 28, 2017

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Title

Austalides S-U, New Meroterpenoids from the Sponge-Derived Fungus Aspergillus aureolatus HDN14-107

Author

Jixing Peng, Xiaomin Zhang, Wei Wang, Tianjiao Zhu, Qianqun Gu, Dehai Li

Year

2016

Journal

Marine Drugs

Abstract

Three new meroterpenoids, named austalides S-U (1–3), were isolated from the culture of a sponge-derived fungus Aspergillus aureolatus HDN14-107, together with eleven known austalides derivates (4–14). Their structures, including absolute configurations, were assigned on the basis of NMR, MS data, and TDDFT ECD calculations. Compound 1 is the first case of austalides with the terpene ring fused to the chroman ring in trans configuration. Compounds 3 and 5 exhibited activities against influenza virus A (H1N1), with IC50 values of 90 and 99 μM, respectively.

Full Article

http://www.mdpi.com/1660-3397/14/7/131/htm

Instrument

J-715

Keywords

Circular dichroism, Absolute configuration, Pharmaceutical