Azaphilones isolated from an alga-derived fungus Penicillium sp. ZJ-27

By Liu-hong Zhang, Yi Long, Xiao-ling Lei, Jia-yi Xu, Zhi-jian Huang, Zhi-gang She, Yong-cheng Lin, Jing Li, Lan Liu

July 28, 2017

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Title

Azaphilones isolated from an alga-derived fungus Penicillium sp. ZJ-27

Author

Liu-hong Zhang, Yi Long, Xiao-ling Lei, Jia-yi Xu, Zhi-jian Huang, Zhi-gang She, Yong-cheng Lin, Jing Li, Lan Liu

Year

2016

Journal

Phytochemistry Letters

Abstract

Four new azaphilones, peniazaphilones A–D (1–4), together with four analogues (5–8), were isolated from the alga-derived fungus Penicillium sp. ZJ-27. The structures of 1–8were elucidated by 1D and 2D NMR analysis. The absolute configurations of 1–4 were determined by electronic circular dichroism (ECD). The isolated compounds were evaluated for cytotoxic activity against two tumor cell lines and antibacterial activities against twelve aquatic pathogenic bacteria.

Full Article

http://www.sciencedirect.com/science/article/pii/S1874390016301951

Instrument

J-810

Keywords

Circular dichroism, Absolute configuration, Pharmaceutical