Title
Bioactive azaphilones from the fungus Penicillium multicolor CM01
Author
Chulida Hemtasin, Somdej Kanokmedhakul, Panawan Moosophon, Kasem Soytong, Kwanjai Kanokmedhakul
Year
2016
Journal
Phytochemistry Letters
Abstract
Two new azaphilones, dechloroisochromophilone II (1) and epi-isochromophilone III (2), a new natural product, 5-hydroxy-4-methoxy-5,6-dihydro-2H-pyran-2-one (3), together with eleven known compounds, 4–14 were isolated from the fungus, Penicillium multicolor CM01. Their structures were elucidated by spectroscopic methods. Compounds 2, 8, 10 and 11 exhibited antimalarial activity against Plasmodium falciparum (IC50 2.1–7.8 μg/mL), while compounds 9 and 10 showed antimycobacterial activity against Mycobacterium tuberculosis (MIC 6.2 and 50.0 μg/mL, respectively). Compounds 2, 4, and 7–11 showed cytotoxicity against three cancer cell lines, KB, MCF-7 and NCI-H187 (IC50 2.2–35.2 μg/mL). In addition, compounds 1, 5–8 and 11 showed a minimum inhibition requirement to acetylcholinesterase (AChE) assay in the range of 0.03–0.25 nM.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Agricultural and environmental, Medicinal