Caesalpinone A, a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, from the pods of Caesalpinia spinosa Kuntze

By Weihua Mu, Hongbo Tang, Yuanping Li, Dongyang He, Ruijing Ma, Liqin Wang

July 28, 2017

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Title

Caesalpinone A, a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, from the pods of Caesalpinia spinosa Kuntze

Author

Weihua Mu, Hongbo Tang, Yuanping Li, Dongyang He, Ruijing Ma, Liqin Wang

Year

2016

Journal

Fitoterapia

Abstract

Caesalpinone A (1), a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, along with ten known sesquiterpenoids (2 − 11) were isolated from the pods of Caesalpinia spinosa Kuntze (Tara). The structure of caesalpinone A was elucidated based on its 1D and 2D NMR spectra. The absolute configuration of 1 was assigned by the comparison of the experimental and calculated electronic circular dichroism spectra. Compound 1 was evaluated for the inhibitory activities against five human tumor cell lines. The sesquiterpenoids of isodaucane skeleton and caryolane skeleton were isolated from Caesalpinia genus for the first time. Compounds 5–9 were firstly reported from Tara.

Full Article

http://www.sciencedirect.com/science/article/pii/S0367326X16301368

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Natural products