Title
Clerodane diterpenoids with potential anti-inflammatory activity from the leaves and twigs of Callicarpa cathayana
Author
Yuan Wang, Jing Lin, Qi Wang, Kun S Hang, De-Bing Pu, Rui-Han Zhang, Xiao-Li Li, Xiao-Chang Dai, Xing-Jie Zhang, Wei-Lie Xiao
Year
2019
Journal
Chinese Journal of Natural Medicines
Abstract
Phytochemical investigation of the leaves and twigs of Callicarpa cathayana led to the isolation of six new clerodane diterpenoids, cathayanalactones A–F (1–6), together with seven analogues (7–13). Their structures were established by extensive NMR analyses together with experimental and calculated ECD spectra analyses. Compounds 1, 2, 3, 7 and 11 showed inhibitory activities on lipopolysaccharide-induced nitric oxide production in RAW264.7 cells.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal