Title
Crotofolane-Type Diterpenoids, Crotocascarins L–Q, and a Rearranged Crotofolane-Type Diterpenoid, Neocrotocascarin, from the Stems of Croton cascarilloides
Author
Susumu Kawakami, Masanori Inagaki, Katsuyoshi Matsunami, Hideaki Otsuka, Masatoshi Kawahata, Kentaro Yamaguchi
Year
2016
Journal
Chemical and Pharmaceutical Bulletin
Abstract
From the stems of Croton cascarilloides, further crotofolane-type diterpenoids, named crotocascarins L–Q (1–6), and a rearranged one (7), named neocrotocascarin were isolated. Their structures were elucidated from spectroscopic evidence. Also, the structures of crotocascarin O (4) and neocrotocascarin (7) were determined by X-ray crystallographic analyses. As a result, neocrotocascarin (7) was found to possess a new carbon framework. A plausible mechanism for the formation of neocrotocascarin (7) is also discussed.
Instrument
J-720
Keywords
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical