Title
Cysteine Residue Containing Merocytochalasans and 17,18-seco-Aspochalasins from Aspergillus micronesiensis
Author
Zhaodi Wu, Xiaotian Zhang, Weaam Hasan Al Anbari, Qun Zhou, Peng Zhou, Mi Zhang, Fanrong Zeng, Chunmei Chen, Qingyi Tong, Jianping Wang, Hucheng Zhu, Yonghui Zhang
Year
2019
Journal
Journal of Natural Products
Abstract
Two cysteine residue containing merocytochalasans (cyschalasins A and B, 1 and 2) and two 17,18-seco-aspochalasins (secochalasins A and B, 3 and 4) were isolated from the endophytic fungus Aspergillus micronesiensis. Cyschalasins A and B represent a new type of merocytochalasan featuring the fusion of an aspochalasin with a modified cysteine residue. Secochalasins A and B are the first 17,18-seco-aspochalasins to be reported and represent a previously undescribed carbon skeleton. Plausible biosynthetic pathways of 1–4 were proposed. Compounds 1 and 2 were cytotoxic and active against Gram-positive bacteria.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Medicinal, Natural products