Cytidine- and guanosine-based nucleotide-lipids

By Bruno Alies, Mohamed Amine Ouelhazi, AMIT NARESHKUMAR PATWA, julien verget, Laurence Navailles, Valérie Desvergnes, Philippe Barthelemy

August 13, 2018

  • Year

  • Technique

  • Industry

Title

Cytidine- and guanosine-based nucleotide-lipids

Author

Bruno Alies, Mohamed Amine Ouelhazi, AMIT NARESHKUMAR PATWA, julien verget, Laurence Navailles, Valérie Desvergnes, Philippe Barthelemy

Year

2018

Journal

Organic & Biomolecular Chemistry

Abstract

Hybrid nucleotide-lipids composed of a lipid covalently attached to purine and pyrimidine nucleobases exhibit supramolecular properties. The novel cytidine and guanosine derivatives are promising bioinspired materials, which can act as supramolecular gelators depending on both the nucleobase and the presence of salts. These supramolecular properties are of broad interest for biomedical applications.

Full Article

http://pubs.rsc.org/en/content/articlelanding/2018/ob/c8ob01023d

Instrument

J-1500

Keywords

Circular dichroism, Biochemistry, Chemical stability, DNA structure, Membrane interactions, Materials