Title
Cytorhizophins A and B, benzophenone-hemiterpene adducts from the endophytic fungus Cytospora rhizophorae
Author
Hongxin Liu, Haibo Tan, Wenxuan Wang, Wenge Zhang, Yuchan Chen, Saini Li, Zhaoming Liu, Haohua Li, Weimin Zhang
Year
2019
Journal
Organic Chemistry Frontiers
Abstract
A pair of novel enantiomeric benzophenone-hemiterpene adducts, (+)-cytorhizophin A (1a) and (−)-cytorhizophin A (1b) as well as cytorhizophin B (2), all of them featuring an unprecedented 6/7/6/7 tetracyclic fused ring system, together with their biosynthetically related precursor cytorhizophin C (3) were isolated from Cytospora rhizophorae A761. Their structures were fully characterized on the basis of extensive spectroscopic analysis, with the absolute configurations of 1 determined by X-ray diffraction and electronic circular dichroism (ECD) calculations. Moreover, compounds 1–3 were evaluated for in vitro antimicrobial activity.
Instrument
J-820
Keywords
Circular dichroism, Absolute configuration, Stereochemistry, Cotton effect, Materials, Organic chemistry