Title
Cytotoxic plicamine alkaloids from the whole plants of Zephyranthes grandiflora
Author
Qiao Yang
Year
2021
Journal
Journal of Asian Natural Products Research
Abstract
Phytochemical investigation on the 80% EtOH extract of the whole plants of Zephyranthes grandiflora afforded three new 4a-epi-plicamine-type alkaloids, zephyranthines A-C (1-3). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (1H-1H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. All the alkaloids were in vitro evaluated for their cytotoxic activities against six glioma cell lines (CHG-5, SH-SY5Y, SHG-44, U251, U343, and GL15). Alkaloids 2 and 3 exhibited significant cytotoxic activities against all tested cell lines with IC50 values of less than 20 μM.
Instrument
P2000,V-650,FT/IR-4100
Keywords
Zephyranthes grandiflora, 4a-epi-plicamine-type alkaloids, zephyranthines A-C