Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina

By Sutin Kaennakam, Pongpun Siripong, Santi Tip-pyang

July 28, 2017

  • Year

  • Technique

  • Industry

Title

Cytotoxicities of two new isoflavanes from the roots of Dalbergia velutina

Author

Sutin Kaennakam, Pongpun Siripong, Santi Tip-pyang

Year

2016

Journal

Journal of Natural Medicines

Abstract

Two new isoflavanes, dalvelutinanes A (1) and B (2), along with three known isoflavanes (3–5) were isolated from the roots of Dalbergia velutina. Their chemical structures, including their absolute configurations, were determined by spectroscopic analysis (1D and 2D NMR, HRESIMS, and CD). All isolated compounds were evaluated for their in vitro cytotoxicities against five human cancer cell lines (KB, HeLa-S3, MCF-7, HepG-2, and HT-29). Compound 5 showed significant cytotoxicity against all of the tested cancer cell lines, with IC50 values in the range 3.47–9.76 µM. In addition, compound 3 showed significant cytotoxicity against the KB and HeLa-S3 cells, with IC50 values of 8.29 and 9.54 µM, respectively, and compound 2 showed significant cytotoxicity against the MCF-7 cell line, with an IC50 value of 4.69 µM.

Full Article

http://link.springer.com/article/10.1007/s11418-016-1039-4

Instrument

J-815

Keywords

Circular dichroism, Absolute configuration, Natural products