Title
Decomposition of amyloid fibrils by NIR-active upconversion nanoparticles
Author
Takunori Harada, Hiraku Matsuzaki, Ryohei Oyama, Takuma Takeuchi, Tomoaki Takei, Taisuke Ninomiya, Kouta Takami, Takanori Inoue, Hiroyasu Nishiguchi, Emi Hifumi, Hiroyuki Shinto, Hiromi Takahashid and Kazuo Umemurae
Year
2020
Journal
Photochemical and Photobiological Sciences
Abstract
We demonstrate amyloid fibril (AF) decomposition induced by NIR-active upconversion nanoparticles complexed with photosensitisers. The process is triggered by upconversion, which initiates a photochemical reaction cascade that culminates in the generation of the highly reactive singlet-oxygen product 1O2 close to the amyloid superstructures, resulting in AF decomposition.
Instrument
FP-8300 and J-820
Keywords
Amyloid proteins, nanoparticles, protein-folding diseases, FRET, Circular dichroism, Fluorescence, UV-visible spectroscopy, Fluorescence up-conversion, Alzheimer’s Disease, Parkinson’s Disease