Title
Depsidones and a dihydroxanthenone from the endophytic fungi Simplicillium lanosoniveum (J.F.H. Beyma) Zare & W. Gams PSU-H168 and PSU-H261
Author
Vatcharin Rukachaisirikul, Supaporn Chinpha, Praphatsorn Saetang, Souwalak Phongpaichit, Siriporn Jungsuttiwong, Sarinya Hadsadee, Jariya Sakayaroj, Sita Preedanon, Prapapan Temkitthawon, Kornkanok Ingkaninan
Year
2019
Journal
Fitoterpia
Abstract
Three new compounds including two depsidones (simplicildones J and K) and one dihydroxanthenone (globosuxanthone E) together with nine known compounds were obtained from the crude extracts of two endophytic fungi Simplicillium lanosoniveum (J.F.H. Beyma) Zare & W. Gams PSU-H168 and PSU-H261 which were isolated from the leaves of Hevea brasiliensis. The structures were elucidated by spectroscopic evidence. The absolute configuration of globosuxanthone E was established by means of experimental and calculated TDDFT ECD data. Simplicildone K exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus with equal MIC values of 128 μg/mL. Simplicildone K and globosuxanthone E displayed antifungal activity against Cryptococcus neoformans ATCC90113 with the same MIC values of 32 μg/mL. In addition, known botryohordine C and simplicildone A showed phosphodiesterase 5 inhibitory activity with the IC50 values of 5.69 and 9.96 μM, respectively, and were noncytotoxic toward noncancerous Vero cells.
Instrument
J-815
Keywords
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical