Title
Development of hollow/porous calcium pectinate beads for floating-pulsatile drug delivery
Author
Shraddha S.Badve, Praveen Sher, Aruna Korde, Atmaram P.Pawar
Year
2007
Journal
European Journal of Pharmaceutics and Biopharmaceutics
Abstract
The purpose of this work was to develop hollow calcium pectinate beads for floating-pulsatile release of diclofenac sodium intended
for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase
followed by a burst release. To overcome limitations of various approaches for imparting buoyancy, hollow/porous beads were prepared
by simple process of acid-base reaction during ionotropic crosslinking. The floating beads obtained were porous (34% porosity), hollow
with bulk density <1 and had Ft50% of 14–24 h. In vivo studies by gamma scintigraphy determined on rabbits showed gastroretention of
beads up to 5 h. The floating beads provided expected two-phase release pattern with initial lag time during floating in acidic medium
followed by rapid pulse release in phosphate buffer. This approach suggested the use of hollow calcium pectinate microparticles as promising
floating-pulsatile drug delivery system for site- and time-specific release of drugs acting as per chronotherapy of diseases.
2006 Elsevier B.V. All rights reserved.
Instrument
FTIR 5300
Keywords
FTIR Microscopy, Floating-pulsatile, drug delivery, Calcium pectinate beads, Diclofenac sodium, Hollow beads, Gamma scintigraphy, Chronotherapy