Development of hollow/porous calcium pectinate beads for floating-pulsatile drug delivery

September 22, 2019

Title

Development of hollow/porous calcium pectinate beads for floating-pulsatile drug delivery

Author

Shraddha S.Badve, Praveen Sher, Aruna Korde, Atmaram P.Pawar

Year

2007

Journal

European Journal of Pharmaceutics and Biopharmaceutics

Abstract

The purpose of this work was to develop hollow calcium pectinate beads for floating-pulsatile release of diclofenac sodium intended
for chronopharmacotherapy. Floating pulsatile concept was applied to increase the gastric residence of the dosage form having lag phase
followed by a burst release. To overcome limitations of various approaches for imparting buoyancy, hollow/porous beads were prepared
by simple process of acid-base reaction during ionotropic crosslinking. The floating beads obtained were porous (34% porosity), hollow
with bulk density <1 and had Ft50% of 14–24 h. In vivo studies by gamma scintigraphy determined on rabbits showed gastroretention of beads up to 5 h. The floating beads provided expected two-phase release pattern with initial lag time during floating in acidic medium followed by rapid pulse release in phosphate buffer. This approach suggested the use of hollow calcium pectinate microparticles as promising floating-pulsatile drug delivery system for site- and time-specific release of drugs acting as per chronotherapy of diseases. 2006 Elsevier B.V. All rights reserved.

Instrument

FTIR 5300

Keywords

FTIR Microscopy, Floating-pulsatile, drug delivery, Calcium pectinate beads, Diclofenac sodium, Hollow beads, Gamma scintigraphy, Chronotherapy