Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

By Dongsheng Fan, Guo-Yuan Zhu, Ting Li, Zhi-Hong Jiang, Li-Ping Bai

July 28, 2017

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  • Industry

Title

Dimacrolide Sesquiterpene Pyridine Alkaloids from the Stems of Tripterygium regelii

Author

Dongsheng Fan, Guo-Yuan Zhu, Ting Li, Zhi-Hong Jiang, Li-Ping Bai

Year

2016

Journal

Molecules

Abstract

Two new dimacrolide sesquiterpene pyridine alkaloids (DMSPAs), dimacroregelines A (1) and B (2), were isolated from the stems of Tripterygium regelii. The structures of both compounds were characterized by extensive 1D and 2D NMR spectroscopic analyses, as well as HRESIMS data. Compounds 1 and 2 are two rare DMSPAs possessing unique 2-(3′-carboxybutyl)-3-furanoic acid units forming the second macrocyclic ring, representing the first example of DMSPAs bearing an extra furan ring in their second macrocyclic ring system. Compound 2 showed inhibitory effects on the proliferation of human rheumatoid arthritis synovial fibroblast cell (MH7A) at a concentration of 20 μM.

Full Article

http://www.mdpi.com/1420-3049/21/9/1146/htm

Instrument

J-1500

Keywords

Circular dichroism, Stereochemistry, Natural products, Medicinal