Title
Dimeric Pyranonaphthoquinone Glycosides with Anti-HIV and Cytotoxic Activities from a Soil-Derived Streptomyces
Author
Mariachiara Trapani, Maria Angela Castriciano, Andrea Romeo, Giovanna De Luca, Nelson Machado, Barry D. Howes, Giulietta Smulevich, Luigi Monsù Scolaro
Year
2019
Journal
Nanomaterials
Abstract
The interaction between gold sub-nanometer clusters composed of ten atoms (Au10) and tetrakis(4-sulfonatophenyl)porphyrin (TPPS) was investigated through various spectroscopic techniques. Under mild acidic conditions, the formation, in aqueous solutions, of nanohybrid assemblies of porphyrin J-aggregates and Au10 cluster nanoparticles was observed. This supramolecular system tends to spontaneously cover glass substrates with a co-deposit of gold nanoclusters and porphyrin nanoaggregates, which exhibit circular dichroism (CD) spectra reflecting the enantiomorphism of histidine used as capping and reducing agent. The morphology of nanohybrid assemblies onto a glass surface was revealed by atomic force microscopy (AFM), and showed the concomitant presence of gold nanoparticles with an average size of 130 nm and porphyrin J-aggregates with lengths spanning from 100 to 1000 nm. Surface-enhanced Raman scattering (SERS) was observed for the nanohybrid assemblies.
Full Article
Instrument
J-720, FP-750
Keywords
Circular dichroism, Stereochemistry, Nanostructures, Fluorescence, Aggregation, Chemical stability, Materials, Biochemistry