Title
Discovery of aromadendrane anologues from the marine-derived fungus Scedosporium dehoogiiF41-4 by NMR-guided isolation
Author
Kun-Chao Hu, Meng-Yang Xu, Hou-Jin Li, Jie Yuan, Ge Tang, Jun Xu, De-Po Yang, Wen-Jian Lan
Year
2016
Journal
RSC Advances
Abstract
Eight closely biogenetically-related aromadendrane-type sesquiterpenoids, six of them new, scedogiines A–F (1–3, 6–8), together with a new polyketide scedogiine G (9) were discovered from the culture broth of the marine-derived fungus Scedosporium dehoogii F41-4 by NMR-guided isolation. Their structures were determined from extensive NMR and HR-ESI-MS data. The absolute configurations of the new sesquiterpenoids were elucidated by ECD calculation. Plausible biogenetic pathways of the aromadendrane analogues were postulated.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical