Title
Diterpenes from Grangea maderaspatana
Author
Fang-Rong Chang, Shih-Ting Huang, Chih-Chuang Liaw, Ming-Hong Yen, Tsong-Long Hwang, Ching-Yeu Chen, Ming-Feng Hou, Shyng-Shiou Yuan, Yuan-Bin Cheng, Yang-Chang Wu
Year
2016
Journal
Phytochemistry
Abstract
Phytochemical investigation of the ethanolic extract of Grangea maderaspatana led to isolation of gramaderins A–D, together with thirteen known compounds. All isolates were assayed for their anti-inflammatory activities. Consequently, 5,7-dihydroxy-3,6,3′,4′,5′-pentamethoxyflavone and 5,3′-dihydroxy-3,6,7,4′,5′-pentamethoxyflavone showed significant bioactivities by inhibiting superoxide anion generation. 8-Acetoxy-pentadeca-1,9Z,14-trien-4,6-diyne-3-ol also demonstrated potent inhibition on elastase release. The gramaderins A/C (β-alkyl linked γ-lactone) and gramaderins B/D (α-alkyl linked γ-lactone) co-exist in this plant material, of which the latter derivatives are few in nature. Gramaderins C/D possess a special linear dilactone diterpene skeleton, which never been reported.
Instrument
J-810
Keywords
Circular dichroism, Stereochemistry, Natural Products, Pharmaceutical