Title
Dual drug release from hydrogels covalently containing polymeric micelles that possess different drug release properties
Author
Mari Murata, Yusuke Uchida, Taku Takami, Tomoki Ito, Ryosuke Anzai, Seiichi Sonotaki, Yoshihiko Murakami
Year
2017
Journal
Colloids and Surfaces B: Biointerfaces
Abstract
In the present study, we designed hydrogels for dual drug release: the hydrogels that covalently contained the polymeric micelles that possess different drug release properties. The hydrogels that were formed from polymeric micelles possessing a tightly packed (i.e., well-entangled) inner core exhibited a higher storage modulus than the hydrogels that were formed from the polymeric micelles possessing a loosely packed structure. Furthermore, we conducted release experiments and fluorescent observations to evaluate the profiles depicting the release of two compounds, rhodamine B and auramine O, from either polymeric micelles or hydrogels. According to our results, (1) hydrogels that covalently contains polymeric micelles that possess different drug release properties successfully exhibit the independent release behaviors of the two compounds and (2) fluorescence microscopy can greatly facilitate efforts to evaluate drug release properties of materials.
Instrument
FP-6500
Keywords
Fluorescence, Vesicle interactions, Polymers, Biochemistry