Title
Fabrication of One- and Two-Dimensional Gold Nanoparticle Arrays on Computationally Designed Self-Assembled Peptide Templates
Author
Yu Tian, Huixi Violet Zhang, Kristi L. Kiick, Jeffery G. Saven, Darrin J. Pochan
Year
2018
Journal
Chemistry of Materials
Abstract
Templating methods, combined with colloidal chemistry synthesis, provide a strategy to fabricate inorganic nanomaterials with controllable architectures. Computationally designed peptide assemblies allow fine control of templated nanomaterial architecture and morphology. Computationally designed peptide sequences, which can self-assemble into peptide nanotubes and peptide platelets, are modified with cysteine amino acids for the purpose of gold nanoparticle templating. The resulting gold nanoparticles exhibit clear one-dimensional and two-dimensional interparticle organizations due to the templating effect of the peptide assemblies. The self-assembly of the computationally designed peptides proceeds via controlled, kinetic pathways that allow manipulation of final peptide assembly nanostructure. As a result of the assembly process, the peptides in different assembled states can be used to control the organization of gold nanoparticles. This work demonstrates a new use of computationally designed peptide assemblies for inorganic nanomaterials construction.
Instrument
J-820
Keywords
Circular dichroism, Secondary structure, Thermal stability, Biochemistry, Materials