Title
First Occurrence of Megastigmane Glucosides in a Plant of Retama Genus
Author
Sara Ouissem Bensaid, Marianna Carbone, Letizia Palomba, Sabrina Bicha, Ali Bentamene, Arianna Carannante, Margherita Gavagnin, Maria Letizia Ciavatta
Year
2022
Journal
Chemistry & Biodiversity
Abstract
Chemical investigation of Retama sphaerocarpa collected in Algeria resulted in the isolation of two megastigmane glucosides, compounds 1 and 2, along with a series of isoflavones and phenol derivatives. Compound 1, named retamoside, was new and its structure was determined by extensive application of spectroscopic methods, including HRMS, 1D and 2D NMR and CD. The anti-inflammatory properties of co-occurring main megastigmane, saurobaccioside B (2) and structurally related vomifoliol (3) on LPS-stimulated murine macrophages RAW 274.7 have been evaluated.
Instrument
V-650, J-815, LC-4000
Keywords
inflammatory, macrophages, RAW 274.7