Functional mesoporous silica nanoparticles (MSNs) for highly controllable drug release and synergistic therapy
Yin-Jia Cheng, Xuan Zeng, Dong-Bing Cheng, Xiao-Ding Xu, Xian-Zheng Zhang, Ren-Xi Zhuo, Feng He
Colloids and Surfaces B: Biointerfaces
Synergistic therapy involving two or more therapeutic agents with different anticancer mechanisms represents a promising approach to eradicate chemotherapy-refractory cancers. However, the preparation of a synergistic therapy platform generally involves complicated procedures to encapsulate different therapeutic agents and thereby increases the purification difficulty. In this work, we reported a simple but robust strategy to prepare a highly controllable drug delivery system (DDS) for synergistic cancer therapy. To construct this robust DDS, mesoporous silica nanoparticles (MSNs) were employed as a nanoplatform to encapsulate anticancer drug doxorubicin (DOX). After using a tumor-targeting cellular membrane-penetrating peptide (TCPP) and a mitochondria-targeting therapeutic peptide (TPP) to seal the surface pores via disulfide bonds, these newly developed MSNs can target cancer cells, penetrate cell membrane and rapidly release anticancer drug and mitochondria-targeted peptide in cytoplasm, inducing a remarkable synergistic anticancer effect. The new design concept reported here will promote the development of targeted and smart DDSs for synergistic cancer therapy.
Circular dichroism, Secondary structure, Nanostructures, Pharmaceutical, Biochemistry, Materials