Title
Functional mesoporous silica nanoparticles (MSNs) for highly controllable drug release and synergistic therapy
Author
Yin-Jia Cheng, Xuan Zeng, Dong-Bing Cheng, Xiao-Ding Xu, Xian-Zheng Zhang, Ren-Xi Zhuo, Feng He
Year
2016
Journal
Colloids and Surfaces B: Biointerfaces
Abstract
Synergistic therapy involving two or more therapeutic agents with different anticancer mechanisms represents a promising approach to eradicate chemotherapy-refractory cancers. However, the preparation of a synergistic therapy platform generally involves complicated procedures to encapsulate different therapeutic agents and thereby increases the purification difficulty. In this work, we reported a simple but robust strategy to prepare a highly controllable drug delivery system (DDS) for synergistic cancer therapy. To construct this robust DDS, mesoporous silica nanoparticles (MSNs) were employed as a nanoplatform to encapsulate anticancer drug doxorubicin (DOX). After using a tumor-targeting cellular membrane-penetrating peptide (TCPP) and a mitochondria-targeting therapeutic peptide (TPP) to seal the surface pores via disulfide bonds, these newly developed MSNs can target cancer cells, penetrate cell membrane and rapidly release anticancer drug and mitochondria-targeted peptide in cytoplasm, inducing a remarkable synergistic anticancer effect. The new design concept reported here will promote the development of targeted and smart DDSs for synergistic cancer therapy.
Instrument
J-810
Keywords
Circular dichroism, Secondary structure, Nanostructures, Pharmaceutical, Biochemistry, Materials