Title
Green and Facile Synthesis of a Theranostic Nanoprobe with Intrinsic Biosafety and Targeting Ability
Author
Cai Zhang, Li Zhou, Jing Zhang, Yan-Yan Fu, Xuejun Zhang, Chunshui Yu, Shao-Kai Sun, Xiu-Ping Yan
Year
2016
Journal
Nanoscale
Abstract
Traditional targeting nanoprobes suffer from the risks of partial loss of targeting activity and nanoparticles aggregation induced by post-modifications, ambiguous toxicity, tedious synthesis procedures and environmentally hazardous processes. Herein, we report a green and facile strategy to fabricate transferrin-indocyanine green nanoparticles as a smart theranostic agent with intrinsic biosafety and active targeting ability for near-infrared fluorescent imaging and photothermal therapy of tumors. Simple mixing of transferrin and indocyanine green enables their self-assembly in aqueous solution to form nanoparticles with excellent water solubility and colloidal stability, favorable biocompatibility and impressive active targeting theranostic effects in vitro and in vivo. The transferrin-Indocyanine green nanoparticles show great potential in theranostic application of tumors in clinic.
Instrument
J-715
Keywords
Circular dichroism, Secondary structure, Nanostructures, Materials, Biochemistry