Title
Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols fromHypericum sampsonii
Author
Wen-Jing Tian, Yu-Qin Qiu, Xiao-Jie Jin, Hai-Feng Chen, Xiao-Jun Yao, Yi Dai, Xin-Sheng Yao
Year
2016
Journal
RSC Advances
Abstract
Five new polycyclic polyprenylated acylphloroglucinols (1–5) with a bicyclo[3.3.1]nonane skeleton, along with five known analogues (6–10), were isolated from the aerial parts of Hypericum sampsonii. Their structures, including the absolute configurations of 1–5, were elucidated by spectroscopic analysis, modified Mosher's method, ECD calculations and in situ dimolybdenum CD method. Besides, all the compounds were evaluated for RXRα transcriptional-inhibitory activities and cytotoxicity against HeLa cells.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Medicinal