Title
Impact of Glycolipids Hydrophobic Chain Length, Headgroup Size on Self-Assembly and Hydrophobic Guest Release
Author
Kanaparedu P C Sekhar, Harikrishna Adicherla, Rati Ranjan Nayak
Year
2018
Journal
Langmuir
Abstract
Encapsulation of hydrophobic guest molecules inside the micelle and their stimuli-sensitive release is a useful strategy for the target-specific drug delivery. Herein, nine bio-based glycolipids were derived from the plant sources. The influence of branching in headgroup on the stability and aggregation pattern in water with different alkyl chain lengths was investigated to deduce the structure-property relationship. External factors, such as temperature, pH, NaCl, and urea concentrations were employed to explore the stimuli-response on the glycolipid nano-assemblies. Further, the solvatochromic dyes, like pyrene, N-phenyl-1-naphthylamine, and curcumin were utilized to examine the hydrophobe loading capacities of these glycolipids assemblies. Fluorescence study was applied to investigate the enzyme-sensitive hydrophobe release. Interestingly, the pH sensitive hydrophobic guests showed pH responsive release from the dynamic micelles. Finally, the synthesized glycolipids revealed their nano-assemblies as smart carriers for hydrophobic cargo.
Instrument
J-810
Keywords
Circular dichroism, Secondary structure, Chemical stability, Nanostructures, Materials, Biochemistry