Title
Inhibition effect of neo-lignans from Eleutherococcus senticosus (Rupt. & Maxim.) Maxim on diacylglycerol acyltransferase (DGAT)
Author
Jia-Lin Li, Na Li, Hyun-Sun Lee, Shan-Shan Xing, Shi-Zhou Qi, Zhen-Dong Tuo, Le Zhang, Xi-Bin Wang, Long Cui
Year
2016
Journal
Phytochemistry Letters
Abstract
Two new neo-lignans, erythro-7E-4′,9′-dihydroxy-4,5′-dimethoxy-5,8′-oxyneolign-7-en-9-al (1) and 4,5′-dimethoxy-lariciresinol (2) together with five known compounds (3-7) were isolated from the EtOAc-soluble extract of Eleutherococcus senticosus (Rupt. & Maxim.) Maxim, and their structures were elucidated on the basis of spectroscopic and physicochemical analyses. All the isolates were evaluated for in vitro inhibitory activity against DGAT1 and DGAT2. Among them, compounds 1 and 3-6 were found to exhibit selective inhibitory activity on DGAT1 with IC50 values ranging from 66.5 ± 1.3 to 111.1 ± 1.4 μM.
Instrument
J-715
Keywords
Circular dichroism, Absolute configuration, Pharmaceutical