Title
Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole “click” ligands
Author
Benjamin J. Pages, Jennette Sakoff, Jayne Gilbert, Yingjie Zhang, Feng Li, Dan Preston, James D. Crowley, Janice R. Aldrich-Wright
Year
2016
Journal
Journal of Inorganic Biochemistry
Abstract
Six platinum(II) complexes of the type [Pt(PL)(AL)]2 +, where PL is a bidentate pyridyl-1,2,3-triazole “click” ligand and AL is the R,R or S,S isomer of 1.2-diaminocyclohexane, have been synthesised and characterised by several methods including elemental microanalysis, proton NMR spectroscopy and X-ray crystallography. The in vitrocytotoxicity of each complex was assessed in eleven cell lines, revealing moderate to good activity for complexes incorporating 2-(1-phenyl-1H-1,2,3-triazol-4-yl)pyridine.
Instrument
J-810
Keywords
Circular dichroism, Coordination chemistry, Stereochemistry, Inorganic chemistry, Biochemistry