Title
Lathyrane‐type diterpenoids from the seeds of Euphorbia lathyrisL. with inhibitory effects on NO production in RAW 264.7 cells
Author
Jin Woo Lee, Qinghao Jin, Hari Jang, Jun Gu Kim, Dongho Lee, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang
Year
2018
Journal
Chemistry & Biodiversity
Abstract
Bioactivity‐guided fractionation of the methanolic extract from the seeds of Euphorbia lathyris led to the isolation of eighteen lathyrane‐type diterpenoids including a new one,Euphorbia Factor L29 (1). Their chemical structures were elucidated by extensive NMR spectroscopic data including 2D‐NMR, and HR‐ESI‐MS as well as CD data. All isolates (1‐18) were found to inhibit the nitric oxide production in LPS‐induced RAW 264.7 macrophages, with their IC50 values in the range of 11.2 ‐ 52.2 μM.
Instrument
J-715
Keywords
Circular dichroism, Absolute configuration, Cotton effect, Pharmaceutical, Biochemistry