Length and sequence effect on the B-Z transition of [d(A-T)n]2 oligonucleotide induced by a cationic porphyrin

By Jong Heon Shin, Yoon Mo Hwang, Yoon Jung Jang, Seog K. Kim

July 28, 2017

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Title

Length and sequence effect on the B-Z transition of [d(A-T)n]2 oligonucleotide induced by a cationic porphyrin

Author

Jong Heon Shin, Yoon Mo Hwang, Yoon Jung Jang, Seog K. Kim

Year

2016

Journal

Biophysical Chemistry

Abstract

trans-BMPyP induced the B-Z transition for alternated AT oligonucleotides as it was evident by inversed CD spectrum. The transition occurred simultaneously with appearance of the extensive stacking of porphyrin. Complete B-Z transition required at least 14 base-pairs long. Insertion of one or two GC base pairs prevented the B-Z transition.

Full Article

http://www.sciencedirect.com/science/article/pii/S0301462216301399

Instrument

J-810

Keywords

Circular dichroism, DNA structure, Ligand binding, Kinetics, Biochemistry