Title
Lignans from the Twigs of Euonymus alatus (Thunb.) Sieb. and their Biological Evaluation
Author
Seulah Lee, Eunjung Moon, Sang Un Choi, Ki Hyun Kim
Year
2016
Journal
Chemistry & Biodiversity
Abstract
A new sesquilignan, euonymolin A (1), and six known lignans, (-)-de-O-methylmagnolin (2), (+)-de-O-methylepimagnolin A (3), (+)-syringaresinol (4), (+)-pinoresinol (5), (+)-medioresinol (6), and (+)-lariciresinol 4’-O-β-D-glucopyranoside (7), were isolated from the twigs of Euonymus alatus (Thunb.) Sieb. (Celastraceae). The structures of the isolated compounds were elucidated based on spectroscopic analyses, including extensive 1D- and 2D-NMR techniques, HRMS analysis and circular dichroism (CD) data, and the literature data. All of the isolated compounds were evaluated for antiproliferative activity against A549, SK-OV-3, SK-MEL-2, and HCT-15 cell lines and inhibition of nitric oxide (NO) production in a lipopolysaccharide (LPS)-activated BV2 cell line. All compounds showed cytotoxicity against the SK-MEL-2 cell line with IC50 values of 23.24-48.14 μM and inhibited NO production in LPS-activated BV-2 cells with IC50 values of 6.75-23.53 μM.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Pharmaceutical