Title
Limonoids with modified furan rings from root barks of Toona sinensis
Author
Jun-He Li, Yi Li, Fa-Liang An, Miao-Miao Zhou, Jie Luo, Kai-Li Jian, Jun Luo, Ling-Yi Kong
Year
2016
Journal
Tetrahedron
Abstract
Toonasinemines A-K (1–12), twelve new azadirone- and gedunin-type limonoids with eight-classes of modified furan rings, were isolated from the root barks of Toona sinensis(A. Juss.) Roem. Their structures were elucidated based on detailed spectroscopic analyses, and the absolute configurations of 1–9 were established by the electronic circular dichroism exciton chirality method. The lactam-bearing moieties in compounds1–7 were rare in limonoids family. Results of bioactivities screening exhibited that 1, 4, and 8 showed moderate cytotoxicities against HepG2, MCF-7, and U2OS human cancer cell lines, and 1, 2, 6, 8, and 9 exhibited marked inhibitory effects on nitric oxide (NO) production in LPS-activated RAW 264.7 macrophages at nontoxic concentration.
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Natural products, Medicinal