Title
Meliacarpinin-Type Limonoids from the Bark of Melia toosendan
Author
Yalin Hu, Li Heng, Rong Xu, Junhe Li, Shanshan Wei, Deran Xu, Jun Luo, Yi Li
Year
2018
Journal
molecules
Abstract
Three new meliacarpinin-type limonoids, toosendanes A–C (1–3), along with three, known meliacarpinins (4–6) were isolated from the bark of Melia toosendan. Their structures, along with their absolute configurations, were elucidated, based on detailed analyses. These included HRESIMS and 1D/2D-NMR, modified Mosher’s method, and electronic circular dichroism (ECD). Limonoids 2 and 3 showed moderate inhibitory activity on LPS-activated, RAW 264.7 macrophages.
Full Article
Instrument
J-810
Keywords
Circular dichroism, Absolute configuration, Cotton effect, Pharmaceutical, Natural products