Title
Mitochondria-Targeting Peptoids
Author
Ho Yeon Nam, Jong-Ah Hong, Jieun Choi, Seungheon Shin, Steve K. Cho, Jiwon Seo, Jiyoun Lee
Year
2018
Journal
Bioconjugate Chemistry
Abstract
Mitochondria-specific delivery methods offer a valuable tool for studying mitochondria-related diseases and provide breakthroughs in therapeutic development. Although several small-molecule and peptide-based transporters have been developed, peptoids, proteolysis-resistant peptidomimetics, are a promising alternative to current approaches. We designed a series of amphipathic peptoids and evaluated their cellular uptake and mitochondrial localization. Two peptoids with cyclohexyl residues demonstrated highly efficient cell penetration and mitochondrial localization without significant adverse effects on the cells and mitochondria. These mitochondria-targeting peptoids could facilitate the selective and robust targeted delivery of bioactive compounds, such as drugs, antioxidants, and photosensitizers, with minimal off-target effects.
Instrument
J-810
Keywords
Circular dichroism, Secondary structure, Chemical stability, Biochemistry